MMP1 and MMP7 as Potential Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis
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چکیده
منابع مشابه
MMP1 and MMP7 as Potential Peripheral Blood Biomarkers in Idiopathic Pulmonary Fibrosis
BACKGROUND Idiopathic pulmonary fibrosis (IPF) is a chronic progressive fibrotic lung disease associated with substantial morbidity and mortality. The objective of this study was to determine whether there is a peripheral blood protein signature in IPF and whether components of this signature may serve as biomarkers for disease presence and progression. METHODS AND FINDINGS We analyzed the co...
متن کاملMolecular biomarkers in idiopathic pulmonary fibrosis.
Molecular biomarkers are highly desired in idiopathic pulmonary fibrosis (IPF), where they hold the potential to elucidate underlying disease mechanisms, accelerated drug development, and advance clinical management. Currently, there are no molecular biomarkers in widespread clinical use for IPF, and the search for potential markers remains in its infancy. Proposed core mechanisms in the pathog...
متن کامل[Serum biomarkers in idiopathic pulmonary fibrosis].
Idiopathic pulmonary fibrosis (IPF) is the most common of interstitial lung diseases and is characterised by a significant mortality rate. That is way both clinicists and patients are interested to identify factors that may influence outcome of disease. This factors are named biological markers or biomarkers. Their usefulness in diagnostic, monitoring and prognosis of interstitial pneumonia, an...
متن کاملMacrophage-Derived Biomarkers of Idiopathic Pulmonary Fibrosis
Idiopathic pulmonary fibrosis (IPF) is a severe, rapidly progressive diffuse lung disease. Several pathogenetic mechanisms have been hypothesized on the basis of the fibrotic lung damage occurring in this disease, and a potential profibrotic role of activated alveolar macrophages and their mediators in the pathogenesis of IPF was recently documented. This paper focuses on recent literature on p...
متن کاملMolecular biomarkers in idiopathic pulmonary fibrosis and disease severity.
Despite major accomplishments in our understanding of idiopathic pulmonary fibrosis (IPF), its diagnosis, and management continues to pose significant challenges. The clinical management of IPF remains a major challenge due to a limited number of effective drug therapies, as well as accurate indicators of disease progression. Most patients die within at least five years after diagnosis. The ide...
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ژورنال
عنوان ژورنال: PLoS Medicine
سال: 2008
ISSN: 1549-1676
DOI: 10.1371/journal.pmed.0050093